Molecular engineering of gene therapies for the nervous system
DNA as medicine
Historical timeline in molecular medicine development
started with small molecules (1908 start)
Protein therapies (1920s start)
gene therapies (1980s had some therapies that were somewhat effective)
Stem cells (1960s start)
More chronic health conditions are now the problems.
Chronic age related disease
alzheimers, parkinsons, etc...
Three problems of gene therapy - delivery, delivery and delivery
Adeno associated virus (5 kilobases - AAV)
60 units of CAP protein assemble to form icosahedral capsid
numerous natural variants have been isolated
non-pathogenic.
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DNA as medicine
Historical timeline in molecular medicine development
started with small molecules (1908 start)
Protein therapies (1920s start)
gene therapies (1980s had some therapies that were somewhat effective)
Stem cells (1960s start)
More chronic health conditions are now the problems.
Chronic age related disease
alzheimers, parkinsons, etc...
Three problems of gene therapy - delivery, delivery and delivery
Adeno associated virus (5 kilobases - AAV)
60 units of CAP protein assemble to form icosahedral capsid
numerous natural variants have been isolated
non-pathogenic.
Read more »
