Ninety percent of children and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy, CTL019, developed at the Perelman School of Medicine at the University of Pennsylvania. Twenty-seven of the 30 patients in the studies achieved a complete remission after receiving an infusion of these engineered “hunter” cells, and 78 percent of the patients were alive six months after treatment.
New York Times reports that other hospitals around the country will soon test the experimental treatment in children with advanced acute lymphoblastic leukemia. Similar research, also with encouraging results, is being done at the National Cancer Institute and Memorial Sloan Kettering Cancer Center in New York. Each year in the United States, acute lymphoblastic leukemia affects about 2,400 people older than 20, and 3,600 younger. It has a cure rate in adults of only about 40 percent, compared with 80 percent to 90 percent in children. About 1,170 adults die from the disease each year, compared with 270 people under age 20.
The New England Journal of Medicine - Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
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New York Times reports that other hospitals around the country will soon test the experimental treatment in children with advanced acute lymphoblastic leukemia. Similar research, also with encouraging results, is being done at the National Cancer Institute and Memorial Sloan Kettering Cancer Center in New York. Each year in the United States, acute lymphoblastic leukemia affects about 2,400 people older than 20, and 3,600 younger. It has a cure rate in adults of only about 40 percent, compared with 80 percent to 90 percent in children. About 1,170 adults die from the disease each year, compared with 270 people under age 20.
The New England Journal of Medicine - Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
Read more »
