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Gene Therapy progress with clinical trials, possible cures and major investment

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Pfizer is establishing a gene therapy platform to study potential treatments, led by a top UK expert, and had struck a deal with privately owned U.S. biotech firm Spark Therapeutics to develop a treatment for haemophilia.

The Spark program is expected to enter early-stage clinical trials for haemophilia B in the first half of 2015. Spark will be responsible for the early Phase I/II tests, with Pfizer taking over late-stage studies, any regulatory approvals and potential commercialization.

Spark will get $20 million upfront and be eligible for additional payments based on product success worth up to $260 million.

Pfizer's research effort in gene therapy will be led by Michael Linden, a professor from King’s College London and director of the University College London Gene Therapy Consortium. Linden is joining Pfizer on a two-year secondment.

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