China has created genetically modified monkeys using a new method of DNA engineering known as Crispr. The infant macaques show that targeted genome editing is feasible in primates—a potential boon for scientists studying complex diseases, including neurological ones, and an advance that suggests that the method could one day work in humans.
The new study shows for the first time that Crispr can create viable primates with genomes modified at specific targeted genes.
The Chinese researchers injected single-cell macaque embryos with RNAs to guide the genome-editing process. The team modified three genes in the monkeys: one that regulates metabolism, another that regulates immune cell development and a third that regulates stem cells and sex determination.
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Cell Journal - Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
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The new study shows for the first time that Crispr can create viable primates with genomes modified at specific targeted genes.
The Chinese researchers injected single-cell macaque embryos with RNAs to guide the genome-editing process. The team modified three genes in the monkeys: one that regulates metabolism, another that regulates immune cell development and a third that regulates stem cells and sex determination.
Cell Journal - Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
Read more »
